Streets of Rage II
Widely considered the greatest side-scrolling beat-'em-up of the 16-bit era — and home to one of the best video-game soundtracks ever made. Axel, Blaze, Max, and Skate vs. Mr. X's syndicate on the Sega Genesis.
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ToeJam & Earl
Two alien rappers from the planet Funkotron crash-land on Earth after Earl's terrible piloting, and the result is one of the weirdest, chillest games the Genesis ever got: random floating islands, mystery presents, tomato-throwing, and a split screen that healed itself when you and your buddy walked back together.