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The cheerleader who was also the chosen one. Sarah Michelle Gellar's Buffy Summers staked vampires over the Hellmouth beneath her high school, and the show's mix of monster-of-the-week horror, teen angst, and quippy dialogue made it a genre-defining WB touchstone.
Three sisters, one Book of Shadows, and the Power of Three. Charmed premiered on The WB on October 7, 1998, to 7.7 million viewers, the network's biggest debut ever, and ran eight seasons through 2006, surviving the exit of its eldest sister to become, for a while, the longest-running hour-long show with all-female leads in American TV history.
The Grim Reaper, beaten at limbo by a dim kid and his terrifying friend, becomes their best friend forever. Maxwell Atoms' Cartoon Network series ran from 2001 to 2007, first as half of Grim & Evil and then on its own, with Grim's put-upon drawl and Mandy's scowl carrying six seasons.